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Acetonitrile for UHPLC Hypergradient

Cyanomethane, Ethanenitrile, Methyl Cyanide

Minimum assay (G.C.): 99.9%
Code
721881
CAS
75-05-8
Molecular Formula
CH3CN
Molar mass
41.05 g/mol

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Box prices only valid with purchase of full box.

code packaging size price per unit box price per unit
Code & packaging Price per piece
721881.1612
code
721881.1612
packaging size
2.5 l
price per unit
single 253,80€
box price per unit
215,73€x 4 units
molecule for: Acetonitrile for UHPLC Hypergradient
Melting Point:
-48 °C
Boiling Point:
80 - 82 °C
Density:
0.781 kg/l
Refractive Index:
20/D 1.344
Physical Description:
liquid
Product Code:
721881
Product Name:
Acetonitrile for UHPLC Hypergradient
Quality Name:
for UHPLC Hypergradient
Specifications:
Minimum assay (G.C.): 99.9%
Identity: IR passes test
Density 20/4: 0.779-0.783
Suitability: for pesticide analysis (HPLC UV detection): passes test
Suitability: for PAH analysis (HPLC fluorescence detection): passes test
Suitability: for fluorescence detection ( NIST SRM 1647B): passes test

Maximum limit of impurities
APHA colour: 10
Acidity: 0.0001 meq/g
Alkalinity: 0.0001 meq/g
Non-volatile matter: 0.0001 %
Base line drift (210 nm): 10 mUA
Water (H2O): 0.01 %
Gradient at 210 nm: 1 mUA
Gradient at 254 nm: 0.5 mUA
UV Spectrum (1cm cell; Ref.: water):
Transmittance at 190 nm: ≥30%
Transmittance at 193 nm: ≥60%
Transmittance at 195 nm: ≥85%
Transmittance at 200 nm: ≥96%
Transmittance at 215 nm: ≥98%
Transmittance at 230-400 nm: ≥99%
Data of interest in HPLC:
UV-Cut off: 190 nm
Rohrschneider Polarity: 5.8
Eluotropic value E° (Al2O3): 0.65
Sol. H2O in solv. at 20°C: miscible
Microfiltered product (0.2 μm) and bottled under nitrogen atmosphere.
Hazard pictograms
  • GHS02 Hazard
  • GHS07 Hazard
UN:
1648
Class/PG:
3/II
ADR:
3/II
IMDG:
3/II
IATA:
3/II
WGK:
2
Storage:
Room Temperature.
Signal Word:
Danger
GHS Symbols:
GHS02
GHS07
H Phrases:
H225
H332
H312
H302
H319
P Phrases:
P210
P233
P240
P241
P242
P243
P261
P270
P271
P280
P301+P330+P331
P303+P361+P353
P304+P340
P305+P351+P338
P312
P322
P363
P370+P378
P501
P337+P313
Master Name:
Acetonitrile
Synonyms Long Text:
Cyanomethane, Ethanenitrile, Methyl Cyanide
EINECS:
200-835-2
CS:
2926 90 70
Index Nr.:
608-001-00-3
Download TDS file for complete specifications

FAQs

What is acetonitrile?

Acetonitrile is a polar organic solvent, with the formula CH3CN. It is the organic nitrile with the simplest possible structure. The nitrogen atom in the molecule contains two unpaired electrons which give it its reactivity and stability properties. It is a colorless liquid, widely used because it is miscible with water and a wide variety of organic solvents, with the exception of saturated hydrocarbons (petroleum fractions), has a low melting point and a low absorbance in the near-ultraviolet spectrum (200 nm - 400 nm). Because of this, its applications are many and varied. Acetonitrile is also known as methyl cyanide, cyanomethane or ethanonitrile.

What is acetonitrile used for?

The applications of acetonitrile are many and varied: solvent for butadiene extraction; chemical intermediate for the manufacture of pesticides such as acetamipride; solvent for organic and inorganic compounds. It is also used as a raw material for the production of acetophenone, thiamine, acetamidine, etc.; for the extraction of tars, phenols and colorants in petroleum hydrocarbons (since the latter are insoluble in acetonitrile); in the production of acrylic fibers, manufacture of pharmaceuticals, nitrile rubber, ABS resins, etc. In organic synthesis it is used as an aprotic polar solvent for the preparation of drugs, intermediates, oligonucleotides and peptides. For analytical determinations, high purity acetonitrile is a widely used solvent, being especially suitable for chromatographic techniques. In recent years, the use of Ultra-High Performance Liquid Chromatography (UHPLC) has grown significantly. The increased speed of analysis, high efficiency, high resolution, robustness, reliability and commercial availability of a wide range of UHPLC instruments and stationary phases, with significant improvements in the technology of this equipment (detectors, automatic injectors, pumps, columns, etc.), has led to more and more laboratories acquiring UHPLC equipment and to the development of methods for the analysis of pharmaceuticals, for example, using this technique. To achieve maximum performance of these UHPLC systems, the use of suitable solvents of high purity is recommended to increase detection sensitivity, improve quantification accuracy and protect the UHPLC systems from particulate impurities that can clog and block the system. Acetonitrile is also used in liquid chromatography/mass spectrometry (LC/MS), e.g. for peptide and protein analysis, for spectroscopy, pesticide residue analysis, DNA synthesis, etc.

What are the applications of acetonitrile?

The applications of acetonitrile are many and varied: solvent for butadiene extraction; chemical intermediate for the manufacture of pesticides such as acetamipride; solvent for organic and inorganic compounds. It is also used as a raw material for the production of acetophenone, thiamine, acetamidine, etc.; for the extraction of tars, phenols and colorants in petroleum hydrocarbons (since the latter are insoluble in acetonitrile); in the production of acrylic fibers, manufacture of pharmaceuticals, nitrile rubber, ABS resins, etc. In organic synthesis it is used as an aprotic polar solvent for the preparation of drugs, intermediates, oligonucleotides and peptides. For analytical determinations, high purity acetonitrile is a widely used solvent, being especially suitable for chromatographic techniques. In recent years, the use of Ultra-High Performance Liquid Chromatography (UHPLC) has grown significantly. The increased speed of analysis, high efficiency, high resolution, robustness, reliability and commercial availability of a wide range of UHPLC instruments and stationary phases, with significant improvements in the technology of this equipment (detectors, automatic injectors, pumps, columns, etc.), has led to more and more laboratories acquiring UHPLC equipment and to the development of methods for the analysis of pharmaceuticals, for example, using this technique. To achieve maximum performance of these UHPLC systems, the use of suitable solvents of high purity is recommended to increase detection sensitivity, improve quantification accuracy and protect the UHPLC systems from particulate impurities that can clog and block the system. Acetonitrile is also used in liquid chromatography/mass spectrometry (LC/MS), e.g. for peptide and protein analysis, for spectroscopy, pesticide residue analysis, DNA synthesis, etc.

What is the melting point of acetonitrile?

The melting (freezing) point of acetonitrile is -45 °C.

What is the boiling point of acetonitrile?

The boiling point of acetonitrile is 82 °C.

What is the solubility of acetonitrile?

Acetonitrile is miscible with methanol, ethanol, isopropanol, methyl acetate, ethyl acetate, ether, acetamide solutions, chloroform, carbon tetrachloride, ethylene chloride and with many unsaturated hydrocarbons; immiscible with many saturated hydrocarbons (petroleum fractions).

What is the density of acetonitrile?

The density of acetonitrile is 0.786 g/mL at 25 °C.

What is the dipole moment of acetonitrile?

The dipole moment of acetonitrile is 3.92 D.

What is the dielectric constant of acetonitrile?

The dielectric constant (permittivity) of acetonitrile is 37.5 at 20 °C.

What are the safety precautions for acetonitrile?

The safety indications for acetonitrile according to the CLP (Classification, Labeling and Packaging) Regulation are: H225, H302+H312+H332, H319; P210, P280, P303+P361+P353, P305+P351+P338, P403+P235, P501. The symbols or pictograms according to GHS (Globally Harmonized System of Classification and Labelling of Chemicals) are: GHS02 and GHS07. Acetonitrile is for professional use only. The Safety Data Sheet (SDS) can be consulted by following this link https://www.itwreagents.com/download_file/sds/221881/eu/sds_221881_en.pdf.

Where to buy acetonitrile?

You can purchase PanReac AppliChem brand acetonitrile from ITW Reagents through its worldwide network of distributors, or through the online store if you are a registered ITW Reagents customer. Follow this link to find a distributor in your country https://www.itwreagents.com/rest-of-world/en/distributors-rw. If you wish to purchase acetonitrile for production processes, please contact us directly.